Methylated β-cyclodextrin as P-gp modulators for deliverance of doxorubicin across an in vitro model of blood-brain barrier - Université d'Artois Access content directly
Journal Articles Bioorganic and Medicinal Chemistry Letters Year : 2006

Methylated β-cyclodextrin as P-gp modulators for deliverance of doxorubicin across an in vitro model of blood-brain barrier

Abstract

Co-incubations of various β-cyclodextrins and doxorubicin have been evaluated on an in vitro model of blood-brain barrier in order to increase the delivery of this P-gp substrate to the brain. Among these cyclodextrins used, the Rame-β-cyclodextrin and Crysme-β-cyclodextrin increased the transport by a factor of 2 and 3.7, respectively. This increase was attributed to the cholesterol extraction property of these cyclodextrins from brain capillary endothelial cells leading to a modulation of the P-gp activity.
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Dates and versions

hal-00543357 , version 1 (06-12-2010)

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  • HAL Id : hal-00543357 , version 1

Cite

Sébastien Tilloy, Véronique Monnaert, Laurence Fenart, Hervé Bricout, Roméo Cecchelli, et al.. Methylated β-cyclodextrin as P-gp modulators for deliverance of doxorubicin across an in vitro model of blood-brain barrier. Bioorganic and Medicinal Chemistry Letters, 2006, 16, p. 2154-2157. ⟨hal-00543357⟩
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